ויאמר ד' לה שני גיים בבטנך ושני לאומים ממעיך יפרדו
Rashi explains that the two nations which would descend from the twins within Rivkah’s womb would have two great leaders who were friends. Rabbi Yehudah HaNasi, known as Rebbi, was the redactor of the Mishnah. His contemporary was the Roman emperor, Antoninus, a descendant of Eisav. The Chasam Sofer explains that Rivkah was informed that the twins, Yaakov and Eisav, had the potential to complement one another’s service to Hashem, much like Yissacher who studied Torah supported by his brother, Zevullun. We find that Antoninus was subservient to Rebbi to the point that he enabled him to redact the Mishnah….
